Abstract

MICROWAVE ASSISTED SYNTHESIS OF THE HIAZOLIDINEDIONE DERIVATIVE AS A MEDICINAL USE

Govind R. Daspute*, Mahesh D. Bhalsing and Somnath A. Rasane

ABSTRACT

To further elucidate the chemical mechanism behind the activity seen, further research is warranted into the exceptional features of this novel family of anti-diabetes drugs. It is possible that some of the newer compounds with antidiabetic activity that showed promise can be further developed to have more potency than the conventional medications. Our goal is to create Thiazolidinedione derivatives that are more effective at lowering blood glucose level than currently available derivatives. Results revealed that every final product was a stable, pure chemical. We came to the conclusion that molecular docking, the foundation upon which we constructed molecules, has shown to be promising, at least in these initial in vivo pharmacological screening models, after thoroughly analyzing the pharmacological activities of generated compounds. To offer a thorough profile of these compounds for their potential application in medication therapy, additional pharmacological and toxicological research is necessary. The antidiabetic activity will be carried out using Wister rat and measuring the glucose level by glucometer.

Keywords: Antidiabetic activity, Thiazolidinedione, Molecular Docking, Insulin, PPAR receptors.