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  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

ANTIVIRAL PROPERTY OF CRUDE AQUEOUS AND ALCOHOLIC EXTRACTS OF ANDROGRAPHIC PANICULATA AGAINST HIV (REVERSE TRANSCRIPTASE) AND HBV (SURFACE ANTIGEN AND DNA POLYMERASE)

Vedha Veerasami1, Rajendran Paramasivam2,Gnanasekaran Ashok4, Murugesan Karthikeyan 5, Anushka Shanmugam3, Kannan Mohan6, Sri Priya M7 and Selvarani P8

1Department of Microbiology, Madras Christian College, Chennai, Tamilnadu, India
2Department of Microbiology, Sri Ramachandra Medical College, Porur, Chennai, T.N. India
3Division of Virology and Immunology, Department of Microbiology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, T.N. India.
4Biotechnology, Faculty of Integrative Sciences & Technology, Ipoh, Malaysia.
5Microbiology Unit, Faculty of Medicine, Quest International University, Perak, Ipoh, Malaysia.
6Department of Biotechnology and Research, KVM College of Engineering & Information Technology, Cherthala, Kerala, India.
7Department of Microbiology, Karpagam University, Eachanari, Coimbatore, T.N. India.
8Department of Microbiology, Govt. Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India.

ABSTRACT

Plants and plant derived agents have long history as source of potential chemotherapeutic agents in Ayurvedic and Unani system of medicine. The present study has been aimed to study the HIV (Reverse Transcriptase) and HBV (Surface antigen and DNA polymerase by Andrographic paniculata. The plant extract of the Andrographic paniculata has positive inhibitory effect on ethanol.methanol and aqueous extracts of a Andrographic paniculata showed positive inhibition against HIV-RT,HBsAg and HBV DNA Polymerase whereas petroleum ether, hexane and chloroform extracts did not inhibit both HIV and HBV . This is probably the first authentic scientific antiviral report from South India on Andrographic paniculata.Further investigations on the phytochemical of the compounds and the structure elucidation is imperative to confirm the same.

Keywords: Andrographic paniculata; Immunomodulation; HBV DNA Polymerase; Cytokine.


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