Abstract

A REVIEW OF SMART EXCIPIENTS IN ORO DISPERSIBLE FILMS FOR ENHANCED DRUG DELIVERY

Umamaheswari D.*, Senthil Prabhu R., Ashwini J., Preethi J., Priya Dharshini S., Preethika M.

ABSTRACT

Orodispersible films (ODFs) are an innovative and patient-centric drug delivery system designed to rapidly disintegrate in the oral cavity without water. They offer significant advantages in terms of patient compliance, particularly among paediatric, geriatric, and dysphasic populations. The success of ODF formulation is highly dependent on the careful selection and optimization of excipients, which are pivotal in ensuring proper film formation, drug stability, mechanical integrity, palatability, and rapid disintegration. This review comprehensively analyses the key classes of excipients employed in ODFs, including film-forming agents, plasticizers, saliva-stimulating agents, taste-masking agents, flavouring agents, and surfactants. It also outlines the selection criteria for these excipients, considering their functional roles, physicochemical compatibility with active pharmaceutical ingredients, and regulatory considerations. Additionally, the article addresses formulation challenges and explores how the strategic use of excipients can overcome these hurdles. A thorough understanding of excipient functionality not only facilitates the rational design of ODFs but also contributes to enhanced therapeutic efficacy and improved patient acceptance.

Keywords: Orodispersible films, Geriatric, Paediatric, Plasticizers, Smart Polymers.