Abstract

REVIEW ON: A FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILMS

Gauri Lahane*, Radhemohan Rathod, Anjali Darade, Jayshri Dikkar, Kalpana Ubale, Nitin Deshmukh

ABSTRACT

The main goal of this study was to make mucoadhesive buccal films and to choose the best one by testing them in the lab. Buccal drug delivery (through the cheek) is seen as a good alternative to swallowing pills because the cheek lining allows drugs to pass through easily and is rich in blood and lymph supply. Lisinopril is a medicine used to treat high blood pressure, but it has only 25% availability in the body when taken by mouth because of first-pass metabolism in the liver. This study aimed to improve the availability of Lisinopril in the body by delivering it through buccal films These films were made using the solvent casting method, with different film-forming materials like CMC, PVP K30, and glycerin (PG) as a plasticizer. Ten different formulations (F1 to F10) of the films were made. They were smooth, The main goal of this study was to make mucoadhesive buccal films and to choose the best one by testing them in the lab. Buccal drug delivery (through the cheek) is seen as a good alternative to swallowing pills because the cheek lining allows drugs to pass through easily and is rich in blood and lymph supply. Lisinopril is a medicine used to treat high blood pressure, but it has only 25% availability in the body when taken by mouth because of first-pass metabolism in the liver. This study aimed to improve the availability of Lisinopril in the body by delivering it through buccal films These films were made using the solvent casting method, with different film-forming materials like CMC, PVP K30, and glycerin (PG) as a plasticizer. Ten different formulations (F1 to F10) of the films were made. They were smooth,

Keywords: Oral films, Lisinopril, CMC, Glycerin, Solvent casting method.