Abstract

FORMULATION AND DEVELOPMENT OF LANTANA CAMARA LINN. AND LIGNOCAINE GEL FOR THE TREATMENT OF PILES

Mayur Gulab Kharat*, Shivani Parmeshwar Chavan, Vedangi Arvind Kulkarni, Om Vasanta Dhage, Dr. Harshal Anwane, Dr. Shivshankar D. Mhaske

ABSTRACT

This study was designed to formulate and evaluate a topical gel containing Lantana camara Linn. (LC) extract and Lignocaine hydrochloride for treatment of hemorrhoids. Results indicates Lantana camara has anti-inflammatory, antimicrobial and wound healing properties therefore the extract was prepared by extracting LC with Soxhlet extraction using ethanol. The preliminary phytochemical tests for active constituents in LC using standard protocols showed that LC contained flavonoids, tannins, alkaloids and triterpenoids. Lignocaine is among the most widely used local anesthetics and provided immediate relief for patients. The gel was formulated with Carbopol 940 as the geling agent and was evaluated for physical appearance, pH, and viscosity. All findings showed that the final formulation was smooth, appropriate for anorectal, displayed a pH between 6.5 and 7.0, and was stable. Overall, the findings indicate a lot of promise with the herbo-anesthetic gel as a safe and affordable alternative treatment for hemorrhoids. The study demonstrated a strong possibility for therapeutic potential and should be explored further in additional clinical research to determine efficacy and patient outcomes.

Keywords: Lantana Camera linn, Lignocaine Gel, Piles, Hemorrhoids, Herbal Medicine.