Abstract

CO-CRYSTALS TECHNOLOGIES: PATENT STRATEGIES AND CHALLENGES

Jessica*, Jasnoor Kaur Chema, Jatin Singh, Satvinder Kaur and Arvinder Kaur

ABSTRACT

The need for cocrystals arose from the limitations of traditional solid forms such as salts, polymorphs, and amorphous solids, especially in the pharmaceutical industry. Many active pharmaceutical ingredients (APIs) suffer from poor aqueous solubility, low bioavailability, poor stability, or unsuitable mechanical properties, which can hinder their effectiveness and manufacturability. Traditional methods like salt formation are only applicable to ionizable compounds, and amorphous forms, while improving solubility, often lack physical stability. This created a need for a more flexible, non-ionization-based strategy to modify and optimize drug properties without altering the molecular structure of the API.

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