Abstract

"FORMULATION AND EVALUATION OF ECZEMA CREAM"

Kalyan Ganesh Wagh*, Sachin S. Dighole, Seema Rathod, Swati S. Rawat and Sunil S. Jaybhaye

ABSTRACT

Atopic Dermatitis, commonly known as eczema, is a common chronic, relapsing skin disease characterized by pruritus, disrupted epidermal barrier function, and immunoglobulin e- mediated sensitization to food and environmental allergens. AD is often called the ―itch that rashes‖ because the itching starts, and then the skin rash follows as a result of scratching. This eczema can cause two types of pigmentation changes that are, Hypopigmentation and Hyperpigmentation. Eczema is a complex disease that arises from interaction between genes and environment. There are 3 classical stages of eczema: infantile, childhood, 1and adulthood. Eczema is a type of condition that causes skin inflammation. Therefore, topical preparations are at core of eczema treatment; these includes topical moisturizers, topical corticosteroids, and topical calcineurin inhibitors.However, even with careful treatment, eczema is likely to relapse. Millions of people worldwide suffer from eczema, a chronic inflammatory skin condition that requires safe and effective treatment solutions. Herbal medicines have gained attention for their potential in managing eczema due to their perceived safety and effectiveness. This study aimed to develop and evaluate a herbal cream using natural ingredients known for their anti-inflammatory, hydrating, and skin-soothing properties. The formulation included aloe vera, neem (Melia dubia extract), and turmeric extract, which were carefully selected for their therapeutic benefits. The cream underwent physicochemical characterization to assess its pH, spreadability, and stability. Additionally, it demonstrated significant anti- inflammatory and antioxidant properties, suggesting its potential in reducing inflammation and oxidative stress associated with eczema. The results indicated that the formulated cream had optimal pH, viscosity, and stability, showing promising effects in alleviating eczema symptoms. Further clinical validation is needed to confirm its efficacy.

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