Abstract

SYNTHESIS AND IN-SILICO STUDY OF NOVEL THIADIAZOLE DERIVATIVE

Krushna B. Jare*, Rameshwar S. Mhaske and Dr. Megha T. Salve

ABSTRACT

Thiadiazole derivatives have gained significant attention in medicinal chemistry due to their diverse pharmacological properties, including antimicrobial, anticancer, and anti-inflammatory activities. In this study, a novel thiadiazole derivative was synthesized through a multistep reaction protocol. To further understand the potential biological interactions of the synthesized molecule, an in silico study was performed involving molecular docking and ADMET prediction. The docking results indicated strong binding affinity towards key biological targets, suggesting promising therapeutic potential. Overall, this integrated approach combining synthetic chemistry, physical characterization, and computational modeling provides a robust framework for the development of new drug candidates based on the thiadiazole scaffold.

Keywords: Thiadiazole Derivative, Synthesis, In Silico Study, Molecular Docking, ADMET Prediction.