Abstract

FORMULATION AND EVALUATION OF ORAL THIN FILMS OF TELMISARTAN USING VARIOUS POLYMERS

*K. Sravani, Dr. Avinash Dundigalla and Dr. A. Yasodha

ABSTRACT

The objective of this research work was the Development and evaluation of Orodispersible film of Telmisartan as model drug. This formulation was aimed to deliver the quick onset of action of drug Telmisartan in the management of hypertension, so as to enhance patient‟s compliance. The orodispersible film of Telmisartan was prepared by solvent casting method. Orodispersible film of Telmisartan was formulated using two different film forming agent HPMC E5 and Pullulan along with crosspovidone as a superdisintegrant. Total six formulations were developed using varying concentration of film forming agents. FTIR compatibility studies showed that there is no interaction between the excipient and the drug. Prepared orodispersible films were subjected to evaluation study like, thickness, weight variation, folding endurance, disintegration time, drug content and % drug release. The thickness and weight variation for all batch formulations were satisfactory and ensuring uniform distribution of drug among films. Folding endurance test for all film formulations was found satisfactory. Confirming optimum flexibility of prepared films using both film forming agents. Drug content values for all formulation was within pharmacopoeial limit and ensuring uniform drug distribution among the tablets formulations. All batch formulations showed lowest disintegration time, meeting the criteria for orodispersible film. Formulation F5 prepared with pullulan showed lowest disintegration time as compared with other formulations. The in vitro dissolution profile of all the formulation showed rapid drug release. The optimized formulation of F5 was consider as the best formulation with respect to drug content, disintegration time, folding endurance and in vitro drug release pattern. The developed formulation F5 was found to be stable during the stability studies for 3 month indicating good stability of the films.

Keywords: Folding endurance, optimized formulation, Orodispersible film, Telmisartan.