Abstract

A BIOINSPIRED INFECTION SENSOR-BASED CLOSED-LOOP PATCH FOR WOUND CARE

Simran Chowdhury, Suman Bhattacharjee, Priyanka Ray* and Prapti Chakraborty

ABSTRACT

Chronic and acute skin wounds pose a significant global healthcare challenge, exacerbated by rising incidences of trauma, diabetes, and antibiotic-resistant infections. Traditional wound management methods are often limited by subjective assessment and inefficient drug delivery, leading to prolonged healing and increased risk of infection. This manuscript presents the development of a bioinspired, infection sensor-based closed-loop patch designed for advanced wound care. The patch integrates microneedle-based drug delivery with a hydrogel-based bioelectronic sensor capable of detecting hyaluronidase (HAase)-a virulence factor secreted by pathogenic bacteria such as Streptococcus spp. and Staphylococcus aureus. By enabling real-time monitoring of infection biomarkers and targeted, on-demand therapeutic release, the system addresses the limitations of conventional wound care. The microneedle array ensures effective penetration and localized delivery of antibacterial agents, nanoparticles, and anti-inflammatory drugs, overcoming biofilm barriers and enhancing drug bioavailability. The closed-loop feedback mechanism allows for precise modulation of therapy in response to the wound microenvironment, promoting faster healing and reducing complications. This approach represents a significant advancement in personalized wound management, offering a promising solution for the early diagnosis, monitoring, and treatment of complex wounds.

Keywords: The closed-loop feedback mechanism allows for precise modulation of therapy in response to the wound microenvironment, promoting faster healing and reducing complications.