Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING FILM OF PROMETHAZINE THEOCLATE

Sooraj Bamnia*, Sunita Sonartiya, Ekta Yadav and Dr. Rajat Pawar

ABSTRACT

The aim of the study is to formulate Mouth dissolving film of promethazine Theoclate for the antiemetic effect and to improve the efficacy and patient compliance. In the present work, an attempt is made to develop Mouth dissolving film of promethazine Theoclate with the use of Hydroxymethyl cellulose (HPMC) as plolymer, Xanthan Gum as binder, PEG As polymer, Citric acid as preservative, sacralose as sweetening agent and menthol as flavoring agent. Solvent casting technique was used to prepare the mouth dissolving film. The formulated fast dissolving film of promethazine the oclate was evaluated for different parameters: weight variations, thickness, folding endurance, Percentage of drug content, Surface pH, Disintegration test, in vitro drug release and Stability study. Based onthis physiochemical characterization in vitro drug release studies of Promethazine Theoclate showed 99% of drug at the end of 8th minutes. The evaluation test for films of Promethazine Theoclate suggest that it is promising to be developed as fast dissolving films with above mentioned excipients which can enhance the release of drug and thereby the bioavailability may be improved and formulations were found to be stable.

Keywords: Mouth dissolving film, promethazine Theoclate, folding endurance, Hydroxymethyl cellulose, In-vitro drug release.