Abstract

STUDIES ON BENZIMIDAZOLE DITHIOCARBAMATE0 DERIVATIVES AS ACETYCHOLINESTERASE INHIBITORS

*U.Abu Mohsen

ABSTRACT

In the current work some benzimidazole derivatives bearing dithiocarbamate were synthesized in order to investigated for their anticholinesterase activity The structures of the obtained final compounds (3a-j) were confirmed by spectral data (1H-NMR, and FAB+-MS) and elemental analysis . Each derivative was evaluated for its ability to inhibit acetyl cholinesterase (AChE) using a modification of Ellman’s spectophotometric method. Compounds 3b, 3c were found to be the most active against anticholinesterase agents due to their inhibitory effect when compared with Donepezil (IC50 =0.054±0.002μM) as a reference drug.

Keywords: benzimidazole, dithiocarbamate, cholinesterase inhibitors.