Abstract

“CURCUMIN IN MODERN MEDICINES”: THERAPEUTIC POTENTIAL AND CHALLENGES

Mansi Bhardwaj, Kajal Choudhary* and Sanjiv Duggal

ABSTRACT

In India, curcuma longa, also known as turmeric, is a widespread and widely used rhizomatous medicinal plant that is a member of the zingiberaceae family. Curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC), often known as curcuminoids, are the chemicals found in turmeric. Curcumin is a tautomeric compound that can be found in organic solvents as an enolic shape and in water as a keto form. Curcumin has several stability and system difficulties that could be effectively remedied with nanotechnology. Curcumin has been studied using nano-based techniques that are intended to decrease toxicity while increasing solubility, bioavailability, and healing effectiveness. This evaluation systematically provides information on the delivery of curcumin to various nanosystems, such as liposomes, nanoemulsions, polymeric micelles, dendrimers, polymeric nanoparticles, solid-lipid nanoparticles, and nanostructured lipid providers, either alone or in combination with other pharmaceuticals.However, due to persistent safety concerns and a lack of regulatory approval, the use of nanocarriers to transport curcumin is still in its infancy. Diabetic retinopathy (DR), a kind of retinal microangiopathy, is caused by diabetes mellitus. It is currently the most prevalent cause of blindness among artists worldwide. Diabetes is becoming more common in younger people, and lifetime treatment is required. Numerous factors influence the pathogenic pathways of DR, including inflammation, oxidative pressure, hyperglycemia, and hyperlipidemia. The current main treatments for DR are vitrectomy, anti-vascular endothelial boom issue (VEGF) treatment, or retinal photocoagulation.

Keywords: Curcuma Longa, Curcumin, Curcuminoids, Nanocarriers, Formulations, Drug delivery, diabetic retinopathy, Anti-oxidants.