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Abstract

GASTRO RETENTIVE DRUG DELIVERY SYSTEM :- A NEW ERA IN NOVEL DRUG DELIVERY SYSTEM

Bhandari Neeraj, Thakur jagrity, Kutlehria abhilash, Verma Pooja

ABSTRACT

Pharmaceutical companies worked with different pharmaceutical product types include products of different administration route (e.g., oral to parenteral), new specific functionality/delivery systems (e.g., immediate release tablet to modified release tablet) and different dosage forms of the same administration route (e.g., capsule to tablet, solution to suspension) [1]. Oral controlled release drug delivery have recently been of increasing interest in pharmaceutical field to achieve improved therapeutic advantages, such as ease of dosing administration, patient compliance and flexibility in formulation [2,3]. Drugs with short half-lives and drugs that easily absorbed from gastrointestinal tract (GIT) are eliminated quickly from the systemic circulation. For these types of drugs the development of oral sustained-controlled release formulations is an attempt to release the drug slowly into the gastrointestinal tract (GIT) and maintain an effective drug concentration in the systemic circulation for a long time. After oral administration, such a drug delivery would be retained in the stomach and release the drug in a controlled manner, so that the drug could be supplied continuously to its absorption sites in the gastrointestinal tract (GIT) [4,2]. But oral sustained drug delivery formulations show some limitations connected with the gastric emptying time; variable and too rapid gastrointestinal transit could result in incomplete drug release from the device into the absorption window leading to diminished efficacy of the administered dose [5,2]. Floating drug delivery system is an approach to prolong gastric residence time, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effects. This drug delivery system not only prolongs GI residence time but does so in an area of the GI tract that could maximize drug reaching its absorption site in solution and hence ready for absorption [6,2]. (Table no. 1) enlists below shows the different dosage forms of FDDS with examples of various drugs [2,5,17].

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