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Abstract

SUPERSATURATED SELF NANOEMULSIFYING TABLETS OF ATORVASTATIN

Sindhu Raavi*, Subramanian S, Surya Kiran Vuddisa

ABSTRACT

Oral route is the most convenient route of administration but it faces the problem of low oral bioavailability. Self emulsifying therapeutic system (SETS) can be used to overcome the problems faced while using low aqueous soluble drugs. These systems form emulsions in situ and also have good stability. This study aimed at investigating the increase in the bioavailability by administering a BCS class II drug, Atorvastatin, in a supersaturated SNEDDS form and was compared to the conventional Atorvastatin tablets. It yielded a formulation with the droplets in the nano size range with good zeta potential. The liquid S-SNEDDS was further made into tablet form for better stability. The prepared formulations were characterized for the size, zeta potential, self emulsification time and drug content. The best formulation showed a 2.5 fold increase in the bioavailability when compared to the marketed formulation.

Keywords: Supersaturated, Self Nanoemulsifying Systems, poor bioavailability, BCS Class II drug.


[Full Text Article]

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