Abstract

DRUG UTILIZATION EVALUATION OF PPI’ S

*Tushar Giram, Gayke Shankar Anil, Salgar Omkar Navnath, Shindalkar Shubhangi Netaji, Dr. Prasad Katare

ABSTRACT

Background: Proton pump inhibitors (PPIs) are extensively used for managing acid-related disorders across various hospital departments. However, inappropriate prescribing can lead to adverse effects and increased costs. A drug utilization review (DUR) is critical to evaluate PPI prescribing patterns and ensure guideline adherence. Objective: This study aimed to assess the utilization of PPIs in a secondary care hospital, focusing on demographic distribution, indications, route of administration, types of PPIs, and co-prescription patterns. Methods: A prospective observational study was conducted on 100 patients prescribed PPIs across various departments in a secondary care hospital. Data on demographics, PPI type, route of administration, duration, and concurrent medications were collected. Appropriateness was evaluated based on clinical guidelines. Descriptive statistics wereused to analyze prescribing trends, with results presented in pie charts and tables. Results: Among 100 patients, 52% were male and 48% were female. The age groups 18–27 years and 58–67 years each accounted for 24% of PPI prescriptions. Omeprazole was prescribed in 68% of cases, while pantoprazole was used in 32%. Oral administration dominated (91%), with intravenous use in 9%. PPIs were frequently co-prescribed with NSAIDs (34%) and antibiotics (28%), reflecting preventive use against gastrointestinal risks. Other co-prescriptions included antihistamines, antipyretics, and miscellaneous combinations, some lacking clear clinical justification, suggesting potential irrational prescribing. Conclusion: The study highlights prevalent PPI use, particularly omeprazole, with a high rate of oral administration and significant co-prescription with NSAIDs and antibiotics. While most prescribing aligns with preventive strategies, certain combinations indicate the need for improved prescriber education and stewardship programs to optimize PPI use, enhance patient safety, and reduce unnecessary healthcare costs.

Keywords: DUE, PPI’s, GERD, Parietal cell, CYP450 metabolism, Antibiotics, NSAID’s, Zollinger-Ellison syndrome, Omeprazole, Pantoprazole, Prospective study.