Abstract

A COMPREHENSIVE STUDY OF CÁSCARA SAGRADA: PHYTOCHEMICAL SCREENING AND EVALUATION

Mrs. Rucha Pusegaonkar*, Mr. Vishal Girbane, Ms. Smital Khaire, Dr. Meera Deshmukh and Dr. Pranati Tilak

ABSTRACT

This study provides a comprehensive examination of Cascara sagrada (Frangula purshiana), a plant native to western North America and belonging to the Rhamnaceae family, widely known for its traditional use as a potent laxative derived from its dried bark. It explores its phytochemical composition, focusing on compounds such as alkaloids, carbohydrates, flavonoids, phenolic compounds, terpenoids, amino acids, proteins, and a range of glycosides, including anthraquinone, cardiac, saponin, and coumarin glycosides, alongside fixed oils, fats, gums, and mucilages. Detailed methodologies are presented, covering plant collection techniques, chemical assays, and evaluation methods such as TLC, phytochemical analysis, extractive value determination, and total ash analysis. The investigation emphasizes the plant's structural components, including the secondary phloem, medullary rays, cortex, and pericarp, while also addressing potential drug interactions. The research delves into cultivation practices, classification, and harvesting techniques, alongside discussions on its morphological characteristics. By analyzing the chemical and medicinal potential of Cascara sagrada, this study offers valuable insights that can facilitate further exploration into its therapeutic applications and scientific advancements.

Keywords: Phytochemical Screening, evaluation, Medicinal Plants, Laxative, taxonomical.