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Abstract

NANOPARTICULATE DRUG DELIVERY SYSTEM OF POORLY WATER SOLUBLE ANTICANCER DRUG AND THEIR INVITRO RELEASE STUDIES

1Krishnapillai.M*, 2 Thirumoorthy.N

1Department Of Pharmaceutics, Karpagam University, Coimbatore, Tamilnadu, India
2Department of Pharmaceutics, Cheran College of Pharmacy, Coimbatore, Tamilnadu, India

ABSTRACT

The objective of this investigation was to develop a microsphere and also attempts were made to control the release of silymarin. Multipleunit of silymarin microspheres was prepared from Ethyl cellulose and EudragitRS100 polymer by using emulsion solvent evaporation method and Ionic cross linking technique.. These microspheres were evaluated for Drug entrapment, Drug loading, Percentage yield Swelling index, scanning electron microscopy and in vitro drug release. All formulations were shows total drug release duration more than 12 hours. It was observed that the result of in-vitro dissolution studies reveals that the formulation ED3 & ES3 gave controlled release pattern.

Keywords: Silymarin, Cellulose microspheres, Eudragit Microspheres, emulsion solvent evaporation method, Ionic cross linking tecninique.


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