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Abstract

PROBABLE SERONEGATIVE NMDA RECEPTOR ENCEPHALITIS: A DIAGNOSTIC AND THERAPEUTIC CHALLENGE

*Lakshmi, Navya P. and Dr. Akhila Ann Cherian

ABSTRACT

NMDA receptor encephalitis is an autoimmune neurological disorder characterized by neuropsychiatric symptoms, cognitive dysfunction, and autonomic instability. While seropositive cases are well-documented, seronegative presentations pose a diagnostic dilemma. This case report describes a probable seronegative NMDA receptor encephalitis in a 9 year old girl who exhibited classical symptoms but tested negative for anti-NMDA receptor antibodies. This report highlights the challenges in diagnosing and managing seronegative cases, emphasizing the importance of clinical suspicion and early immunotherapy.

Keywords: NMDA receptor encephalitis, Seronegative, Diagnostic challenge, Immunotherapy.


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