Abstract

FORMULATION AND EVALUATION OF MULTILAYERED TABLETS OF METFORMIN, TELMISARTAN AND GLIPIZIDE FOR THE COMBINATION THERAPY OF DIABETES AND HYPERTENSION

Mogili Vijaya Krishna*, T. Venkateswara Rao

ABSTRACT

The main aim of the present investigation is to formulate and evaluate the Multi layered tablet for the combination therapy of Diabetes and Hypertension. In the present investigation the multilayered tablet mainly contain three drug layers. The first layer is an immediate release oro dispersible layer, the second layer is conventional release layer & the 3rd layer is sustained release layer to maintain the steady state concentrations of drug in the blood. In present investigation the tablet contain 3 major drugs i.e. Glipizide, Metformin and Telmisartan which are present in different layers. In this Metformin layer is upper layer which is an oro- dispersible layer & is released in the mouth produce immediate action. Metformin has the anti- diabetic activity. Below this a flavor layer is present which gives the sense of taste to the patient .When the patient get the sense of taste immediately he will swallow the remaining tablet. The remaining part of tablet contains two layers. One layer is telmisartan conventional release layer which has anti -hypertensive activity &the second layer is Glipizide sustained release layer which maintain the steady state concentration. It has anti diabetic activity.

Keywords: Glipizide, Metformin and Telmisartan, direct Compression technique, Multi-layer tablet.