Abstract

A COMPREHENSIVE REVIEW OF “SOLID DISPERSION TECHNOLOGY”

Tarun Dhiman, Kavita Kumari* and Sanjiv Duggal

ABSTRACT

This thorough study delves into solid dispersion technology, a critical method for increasing the solubility and bioavailability of poorly soluble medicines, notably in oral solid dosage forms. Depending on the kind of carrier utilized, solid dispersion systems which range from crystalline to amorphous and surfactant-based systems—involve combining hydrophobic medications into hydrophilic carriers. The advantages of solid dispersions are highlighted in the paper, including improved drug porosity and wettability, which result in faster rates of dissolution. It also looks at concerns including handling, production scaling, and stability problems brought on by moisture absorption and recrystallization. In addition to carrier selection criteria, which might include natural, synthetic, or semi-synthetic materials, important preparation methods including melting, solvent evaporation, and hotmelt extrusion are covered. The methods by which solid dispersions increase medication solubility are described, with an emphasis on the molecular interactions between medicines and carriers. The study continues with a discussion of characterization methodologies, possible uses in pharmaceutical formulations, and examples of commercial products that use this technology, emphasizing its relevance in improving drug delivery and therapeutic results.

Keywords: Solid dispersion, carrier, bioavailability, and solubility.