Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

FORMULATION DESIGN OF THERMOSENSITIVE CHITOSAN/POLOXAMER IN SITU GEL FOR OCULAR DELIVERY OF NORFLOXACIN

Santhosh kumar. P*, Kavitha K, M. Rupeshkumar, Jagadeesh singh S.D

East point college of pharmacy, India.

ABSTRACT

To increase the bioavailability and short ocular residence time of Norfloxacin eye drops, aqueous solutions of drug in chitosan/ Pluronic (poloxamer) were prepared. Mixtures of solutions of Pluronic (5- 12.5% w/w) with chitosan (0.1-0.4% w/w) were prepared. The formulations so prepared were in the liquid state at 4C while turned into a gel at the temperature of the Cul-de-sac. Naturals polymers i.e., Poloxamer was used as the polymer which exhibited the phase transition behavior and chitosan was used to improve residence time. Norfloxacin release was determined using a membrane less dissolution model in artificial tear solution up to 8 hours and the samples were analyzed spectrophotometrically at 277nm. The rheological behavior of solutions in response to dilution or temperature changes and also the phase change temperature (PCT) were determined. Antimicrobial effect of the solutions was studied in nutrient agar in comparison to all formulations of Norfloxacin using Pseudomonas aueroginosa, Staphylococcus aureus and E.coli by the agar diffusion test using the cup-plate technique. The formulation consisted of 12.5% Pluronic and 0.4% chitosan, with the highest release efficiency (76.44 0.854) and an acceptable mean release time, is suggested as a suitable ophthalmic preparation for sustained release of Norfloxacin.

Keywords: Chitosan; insitu gels; ocular; Bioavailability; Anti microbial; invitro release.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More