Abstract

ANTIBACTERIAL NANOFIBER PATCH TECHNOLOGY FOR TARGETED ACNE THERAPY

Dnyaneshwari S. Kumbhar*

ABSTRACT

Acne vulgaris is a prevalent skin condition that affects asignificant portion of the global population, often leading toboth physical and emotional distress. Conventional treatments,such as topical antibiotics, face limitations including antibioticresistance, skin irritation, and uneven drug delivery. Inresponse to these challenges, antibacterial nanofiber patcheshave emerged as a promising alternative for targeted acnetherapy. This research explores the development andapplication of nanofiber-based patches for localized, controlled,and sustained drug release directly at the acne site. Thenanofibers, typically fabricated using electrospinningtechniques, offer an increased surface area, enabling efficientdrug loading and enhanced antibacterial activity. These patchescan be designed to release antimicrobial agents such asantibiotics or natural antimicrobial compounds in a controlledmanner, targeting the acne-causing bacteria Propionibacteriumacnes while minimizing systemic exposure and side effects. Additionally, the nanofiberstructure provides a breathable, biocompatible interface that promotes wound healing andreduces inflammation. This innovative approach holds the potential to improve acnetreatment efficacy by ensuring higher therapeutic concentrations at the site of infection whilereducing the risks associated with traditional oral or topical therapies. The paper outlines thefabrication methods, performance characteristics, and potential clinical applications ofantibacterial nanofiber patches in the treatment of acne vulgaris, as well as future directionsfor further optimization and commercialization.

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