Abstract

EFFECT OF AQUEOUS EXTRACT OF CAESALPINIA BONDUC ROOTS ON HEMATOLOGICAL, BIOCHEMICAL PARAMETERS AND BIOMARKERS OF OXIDATIVE STRESS DURING TESTOSTERONE-INDUCED BENIGN PROSTATIC HYPERPLASIA IN RATS

Toure Ouabo José*, Kamagaté Tidiane, Ouattara Abou and Traore Youssouf Zanga

ABSTRACT

Benign prostatic hyperplasia (BPH), which can be caused by an accumulation of testosterone in the blood, has become a major public health problem. The aim of this study was to evaluate the effect of the aqueous extract of Caesalpinia bonduc roots on benign prostatic hyperplasia induced in rats, while dosing a number of haematological, biochemical and oxidative stress biomarker parameters. Male rats were used. One group of rats served as normal controls, while four groups received subcutaneous injections of testosterone propionate for 28 days. Of these four groups, one group of rats received no treatment, while the other three groups of rats received daily oral doses of 200; 400 mg/kg bw of the aqueous extract of Caesalpinia bonduc and 10 mg/kg bw of finasteride respectively for 28 days. The rats were sacrificed at the end of the study, and their blood was collected for biological analysis. The prostates were weighed and used for the determination of malondialdehyde and reduced glutathione. Aqueous extract of C. bonduc at doses of 200 mg/kg bw and 400 mg/kg bw significantly reduced prostatic weight. These extracts had positive effects on hematological and biochemical parameters assessed in benign prostatic hyperplasia. These results justify the use of this medicinal plant in the African pharmacopoeia for the treatment of benign prostatic hyperplasia.

Keywords: Caesalpinia bonduc roots, biochemical parameters, oxidative stress, benign prostatic hyperplasia.