Abstract

DEVELOPMENT AND ASSESSMENT OF HIGH-DENSITY MATRIX TABLETS CONTAINING LANSOPRAZOLE

Pratima Jayasawal*, Ajay Kumar Sah, Hariom Prasad Chaurasiya and Pramod Sarraf

ABSTRACT

Objective: The objective of the current study was to develop and assess high-density matrix tablets of Lansoprazole, a potent anti-ulcer medication, utilizing both natural and synthetic polymers. These high-density matrix tablets were designed to serve as a targeted site for sustained drug release, ensuring prolonged therapeutic action. Methods: Lansoprazole high-density matrix tablets were formulated using the direct compression method, incorporating zinc oxide as a density-enhancing agent along with different polymers such as HPMC K15M, Xanthan gum, and their combination. The formulated tablets were coated with an enteric polymer, hydroxypropyl cellulose phthalate, to provide additional protection. Various evaluation parameters, including weight variation, drug content, hardness, thickness, density, and in-vitro drug release, were analyzed to assess the tablet properties. Results: The compatibility study between the rug and excipients confirmed no significant interactions. The tablets exhibited a density of 1.62 g/cm³, which exceeded that of gastric fluid, ensuring effective retention in the stomach. Among all formulations, F8, which contained a combination of HPMC K15M and Xanthan gum, demonstrated optimal drug release, achieving 89.1% in 8 hours. These findings suggest that high-density matrix tablets of Lansoprazole can effectively bypass extensive first-pass metabolism, thereby enhancing bioavailability.

Keywords: Lansoprazole, High-Density Matrix Tablets, Enteric-Coated Matrix Tablets, Delayed Release, HPMC K15M, Xanthan Gum.