Abstract

KETOPROFEN-EXCIPIENT COMPATIBILITY STUDIES FOR ADVANCED DRUG DELIVERY SYSTEMS DEVELOPMENT

Abdalwali Ahmed Saif, Mahmoud Mahyoob Alburyhi* and Maged Alwan Noman

ABSTRACT

Pharmaceutical manufacturing has largely grown in recent years. This and many other factors have led to the ability of manipulating pharmaceutical dosage forms and routes of administration. One example of such unique dosage forms is Fast Dissolving Tablets (FDTs), which are solid dosage forms intended to be dissolved in mouth in a relatively short time, ranging from a few seconds to up to 3 minutes. In this research, ketoprofen was chosen to be the active pharmaceutical ingredient (API) of Fast Dissolving Tablets formulation, being a model of non-steroidal anti- inflammatory drugs (NSAIDs). Ketoprofen is widely used as an analgesic, anti-inflammatory and antipyretic properties and being so, the faster the effect, the better the dosage form. A total of fourteen formulation of Fast Dissolving Tablets FDTs of Ketoprofen with Superdisintegrants like; croscarmellose sodium and/or crospovidone in different ratios were prepared with a view to increase its effect by decreasing the time required for the drug to be released. Preformulation, formulation and evaluation of Ketoprofen to avoid problems associated with conventional delivery system such as limited permeation, low dissolution and bioavailability and also to improve bioavailability. Preformulation studies parameters were evaluated. It was concludedthat the drug Ketoprofen was found to be compatible with various excipients which were selected for the formulation and development of the Ketoprofen Fast Dissolving Tablets FDTs. Formulation scientist from his experience and knowledge have to significantly in the preformulation study stage and is an important factor in the ADDS (Advanced Drug Delivery Systems) product development process.

Keywords: Ketoprofen, Compatibility, Excipients, Development, Preformulation, Anti-inflammatory agent.