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Abstract

A VALIDATED REVERSE PHASE HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF IRBESARTAN AND AMLODIPINE IN PHARMACEUTICAL DOSAGE FORM

G.Kumara Swamy*, JMR Kumar , J.V.L.N.Seshagiri Rao

ABSTRACT

A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Irbesartan and Amlodipine in bulk and Pharmaceutical dosage forms. The mobile phase consisted of Potassium dihyrogen ortho phosphate pH 3.4 adjusted with ortho phosphoric acid ) in the ratio of 60:40 /v/v delivered at a flow rate of 1.0 ml / min and wavelength of detection at 250 nm. The retention times of Irbesartan and Amlodipine were 5.8 min and 3.1 min respectively. The developed method was validated according to ICH guidelines. The method with high percent recovery and short retention time of Irbesartan and Amlodipine were found to be simple, rapid and reproducible. The proposed method can be used for determination of these drugs in combined dosage forms.

Keywords: Irbesartan and Amlodipine; RP-HPLC; PDA detector; Tablet dosage forms.


[Full Text Article]

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