Abstract

THE COMPARATIVE STUDY ON INVITRO ANTIDIABETIC ACTIVITY OF GYMNEMA SYLVESTRE AND MOMORIDICA CHARANTIA

*B. Sandhya Rani, K. Pavan Aditya, D. Anjali, K. Balu, S. Pravallika, B. Poornima Kameswari

ABSTRACT

The rising incidence of diabetes mellitus has fueled the investigation of alternative treatment options, especially from herbal sources. This research examines the in vitro antidiabetic effects of Gymnema sylvestre (GS) and Momordica charantia (MC), two popular herbal plants historically utilized in diabetes management. The aim was to assess the capacity of these plants to block crucial enzymes linked to glucose metabolism, notably α-amylase and α-glucosidase, which are related to post-meal hyperglycemia. The extracts from the plant were made with ethanol and water-based solvents, and their inhibitory effects were evaluated through standard enzyme inhibition tests. The findings showed that both GS and MC extracts demonstrated considerable α-amylase and α-glucosidase inhibitory activity in a dose-dependent fashion. Extracts of Gymnema sylvestre exhibited stronger inhibition of α-glucosidase, whereas extracts from Momordica charantia revealed significant inhibition of α-amylase. These results indicate that the bioactive compounds found in both plants might be significant in lowering blood sugar levels after meals. The significant effectiveness of GS and MC underscores their promise as supplementary or alternative therapies for managing diabetes. Additional research, particularly in vivo studies, is needed to investigate the mechanisms of action and the clinical significance of these results. This research advocates for the utilization of Gymnema sylvestre and Momordica charantia as important assets in the creation of antidiabetic treatments.

Keywords: Gymnema sylvestre, Momordica charantia, diabetes control, ?-amylase blockade, ?-glucosidase blockade, therapeutic plants, diabetes treatment.