Abstract

EVALUATION OF ENZYMATIC ANTIOXIDANTS IN TYPE 2 DIABETES MELLITUS SUBJECTS ATTENDING FEDERAL TEACHING HOSPITAL OWERRI, IMO STATE

Deborah Chinonso Orji*, D. C. Nwosu, U. C. Edward, Chidiebere Sandra Okoroigwe, Chioma Ukaga, Nwamaka Egbeonu and Emmanuel Ifeanyi Obeagu*

ABSTRACT

Diabetes mellitus is a metabolic disorder caused by either a lack of insulin secretion, impaired insulin action, or both. This study was aimed at the evaluation of serum levels of calcium, phosphate, iron, ferritin, and enzymatic antioxidants activities in type 2 diabetes mellitus patients attending Federal Teaching Hospital Owerri. The cross-sectional study population comprised 50 participants within the age range of 30 and 65years, with age matched control of 50 apparently healthy individuals. Data obtained from the tests carried out by following the manufacturer’s standard operational procedure for approprate method were analysed using Statistical Package for Social Science (SPSS) version 23.0. There were significantly lower levels of glutathione peroxidase (Gpx), catalase, and superoxide dismutase (SOD) (p=0.000 for all) in diabetes mellitus subjects (200.62±31.93 U/L, 47.89±8.88 kU/L, and 113.78±21.34 U/mL, respectively)compared to the control (331.48±80.20 U/L, 63.17±11.34 kU/L, and 159.69±24.33 U/mL, respectively). These findings reveal that measurement of enzymatic antioxidants activity, ferritin and iron might be beneficial in type 2 diabetes mellitus management and prevention of prognostic complications.

Keywords: enzyme, antioxidants, diabetes mellitus.