Abstract

FORMULATION AND IN-VITRO EVALUATION OF PROCHLORPERAZINE BUCCAL TABLETS

Ch. Srikanth*, N. Srinivas

ABSTRACT

The present investigation is concerned with formulation and evaluation of buccal tablets containing antiemetic drug, Prochlorperazine to circumvent the first pass effect and to improve its bioavailability with reduction in dosing frequency and dose related side effects. The tablets were prepared by direct compression method and wet granulation method using different polymers like Carbopol 934 P, HPMC K4M, Sodium alginate, Xanthan gum and PVP K-30 in different concentrations. Tablets were evaluated by different parameters such as thickness, hardness, weight uniformity, content uniformity, swelling index, surface pH, bioadhesive strength and in-vitro drug dissolution study. FTIR studies showed no evidence on interactions between drug, polymers and excipients. The significant differences in the results were observed, which dependent on characteristics and composition of bioadhesive materials used. The in-vitro release of Prochlorperazine was performed under sink conditions (Phosphate buffer pH 6.8, 37±0.5ºC, rpm 70) using USP-XXIV dissolution apparatus type II. The best in-vitro drug release profile was achieved with the formulation F10 which contains the drug, HPMC E15 and HPMC K4M. The formulation F10, containing 3 mg of Prochlorperazine exhibited 8hr sustained drug release i.e., 98.5% with desired therapeutic concentration. The in vitro release kinetics studies reveal that all formulations fit well with zero order kinetics followed by Korsmeyer Peppas, first order and then Higuchi’s model and the mechanism of drug release is non-Fickian diffusion. Drug diffusion from buccal tablets showed apparently zero order kinetics and release mechanism was diffusion controlled after considerable swelling.

Keywords: Prochlorperzine, Antiemetic, Buccal tablets, HPMC K4M, In-vitro drug release, Zero order kinetics.