Abstract

SYSTEMIC LUPUS ERYTHEMATOSUS (SLE), HISTORY OF SLE, EPIDEMIOLOGY, IMMUNOLOGICAL ABNORMALITIES OF SLE, ETIOLOGY

Rana Talib Mohsen*

ABSTRACT

Multiple systems are impacted by the complicated inflammatory illness known as systemic lupus erythematosus (SLE). This intricate process involves environmental, ecological, genetic, and epigenetic factors. Primarily, it initiates the stimulation of immunity, which turn causes T cells to activate autoreactive B cells and deposit resistant developments in tissues. This leads to an autoimmune force affect entire system or just one organ. From very slight self-resolving symptoms to severe, potentially lethal organ involvement, SLE can appear in a number of ways. Clinical and serological heterogeneity significant features of SLE that greatly complicate diagnosis.

Keywords: Systemic Lupus History, Epidemiology, Immunological, Etiology.