Abstract

SPHINGOSOMES AS A NOVEL VESICULAR DRUG DELIVERY SYSTEM FOR ADVANCED THERAPEUTIC APPLICATIONS

Saravanan Jayaraman*, Prakash Settu, Dhamodharan Erulappan, Ahamed Hakeem Mohammed Meeran, Bhuvan Shankar Dhamodaran, Sumathi Arumugam and Sivakumar Thangavelu

ABSTRACT

Lipid-based nanovesicles are formulations that transport hydrophilic, hydrophobic, or amphiphilic medicines or chemicals. They are particularly useful for hydrophilic and irritating medications that can be encapsulated and administered to the target region. They have many advantages over standard formulations. Lipid-based nano vesicular systems will effectively aid medications by addressing concerns of solubility and penetration, hence increasing bioavailability. Lipid-based nanovesicles for transdermal medication delivery are becoming increasingly useful, particularly for hydrophilic medicines. Liposomes, transferosomes, ethosomes, niosomes, ufasomes, Sphingosomes, and pharmacosomes are some examples of lipid-based nanocarriers. This review article summarizes the types, formulation processes, evaluation and research work done on Sphingosomes as a nano vesicular system.

Keywords: Sphingosomes, vesicle, lipids, nano, bilayer.