Abstract

EPIGEN ITIC ADVANCES IN CANCER THERAPY: APPLICATIONS AND INSIGHTS

Goriparthi Manasa**, Gudavalli Mounika, Penugonda Navya, Shamini Devarapalli Kandra Pavani and Padmalatha Kantamaneni

ABSTRACT

Cancer is a traditional genetic diseasewhich can be dictated byalteration in gene expr ession Research on epigenetics has becomecrucial to cancer therapy, opening up new therapeutic options andtailored medicine. DNA methylation, histone modifications, and noncoding RNAs are examples of epigenetic changes that control geneexpression in a ddition to genetic mutations. Tumorigenesis, metastasis,and resistance to traditional treatments are all influenced by theseepigenetic modifications. Targeted treatments to reverse theseabnormalities have been developed as a result of recent development sin our understanding of the significance of epigenetic changes. Clinicalstudies are being conducted on small molecule inhibitors that targetDNA methyltransferases, histone deacetylases, and bromodomainproteins as part of epigenetic based therapeutics. By reactivating tumorsuppressor genes and reestablishing regular cellular processes, thesesubstances have the ability to rewire the epigenetic landscape of tumorcells. Additionally, the integration of epigenetic An overview of howknowledge of epigenetic dysregulation in malignancies has aided in the development ofinnovative cancer treatments is given in this article.

Keywords: epigenetics, Cancer , histone DNA methylation, Gene expressions.