Abstract

TO DEVELOP AND ASSESS THE EFFICACY OF A NOVEL STRETCH MARK CREAM, FOCUSING ON THE STABILITY OF THE FORMULATION, USER ACCEPTABILITY, AND QUALITY OUTCOMES

Priti Bhagat, Piyush Bhosale, Anya Bisht, Durga Boga, Sakshi Borhade and *Prof. Geeta Sahu

ABSTRACT

Striae Distensae (SD), commonly known as stretch marks, are a prevalent dermatological condition characterized by dermal scarring due to the breakdown of collagen and elastin fibers in the skin. SD is especially common in women, affecting areas such as the abdomen, thighs, breasts and buttocks, with significant psychological and aesthetic implications. This paper explores the pathogenesis of SD, highlighting the roles of mechanical stress, hormonal imbalances and alterations in the extracellular matrix. The study delves into the hormonal influences seen during pregnancy and conditions like Cushing syndrome, where increased levels of corticosteroids disrupt collagen synthesis, weakening the skin’s structural integrity. Furthermore, the research investigates biochemical changes at the molecular level, such as the increased production of tropoelastin and fibrillin-1, which fail to mature into functional elastic fibers, contributing to the persistence of SD. Various treatment options are examined, focusing on collagen-stimulating topical formulations likeStriVectin-SD® and Cussons® Mum and Me Bump Stretch Marks Cream, which aim to enhance skin elasticity. While these products show potential, the lack of robust, peer-reviewed clinical evidence limits their efficacy claims. The paper underscores the need for further research into the biological mechanisms behind SD and the development of more effective prevention and treatment strategies.

Keywords: Collagen, Elastin, Elasticity, Stretch Marks Cream.