Abstract

SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND BIOLOGICAL EVALUATION OF TRANSITION METAL COMPLEXES OF NOVEL SCHIFF BASE LIGAND

D. T. Sakhare*

ABSTRACT

The novel Schiff base ligand has been synthesized by the condensation of 2-hydoxy-1-napthaldehyde and 2-amino-4, 6-dimethoxypyrimidine. The Schiff base, 3-{[(4,6-dimethoxypyrimidin-2-yl)imino]methyl}naphthalen-2-ol and its Ni(II) and Zn(II) complexes were synthesised and characterized by FT-IR, 1H-NMR and UV-Vis techniques for the ligands and FT-IR, UV-Vis, all reactions monitored by TLC, molar conductivity and magnetic susceptibility measurements for the corresponding complexes. The complexe is paramagnetic. The results of the molar conductivity measurements indicated that all complexes are non-electrolytes in (DMSO). An octahedral geometry for all the complexes of. The ligands are bidentate, (L8) through phenolic (OH) and azomethine nitrogen. The ligand and its complexes were screened for their antifungal and antibacterial activity against Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme, Aspergllus flavus and Escherichia coli, Salmonella typhi,Staphylococcus aureus, B. subtilis. The result indicated that the complexes exhibited good antifungal and antibacterial activities.

Keywords: Heterocyclic Schiff bases, 2-hydoxy-1-napthaldehyde and 2-amino-4,6-dimethoxypyrimidine, Antimicrobial Activity.