Abstract

1,3,4-OXADIAZOLE - A LEAD MOLECULE IN MEDICINAL CHEMISTRY: A COMPREHENSIVE REVIEW

*Ashwini H. Pagare and Dr. Anwar R. Shaikh

ABSTRACT

1,3,4-oxadiazole is a five membered heterocyclic ring which is versatile lead compound used to design potent bioactive agents. 1,3,4-oxadiazole have shown significant antibacterial and antifungal activity against various strains of microorganisms such as fungi, gram positive and gram negative bacteria’s. A large number of drugs used clinically contains 1,3,4-oxadiazole ring as a structural building block. A capacity of 1,3,4-oxadiazole to undergo variety of chemical reactions such as electrophilic substitution, nucleophilic substitution, thermal & photochemical reaction, which make it medicinal backbone on which number of potential molecules can be constructed. 1,3,4-oxadiazole derivatives and investigations on their chemical and biological activities have gained greater importance and vitality in recent decades for biological, medical and agricultural reasons. Present review is flooded and enriched with reports of antimicrobial activity of 1,3,4-oxadiazle derivatives published in various research papers.

Keywords: 1,3,4-oxadiazole, antibacterial activity, antifungal activity, SAR of reported synthesized 1,3,4-oxadiazole containing drugs.