Abstract

REVIEW ON FLOATING MICROSPHERE OF PIOGLITAZONE

Aniket S. Borase*, Rahul R. Ahire, Lokesh P. Patil, Sanket A. Patil, Rahul G. Arote

ABSTRACT

For any pharmacological molecule, solubility is a crucial physicochemical component that influences both its therapeutic efficacy and absorption. Drug absorption is mostly reliant on how quickly it dissolves. Dissolution is the rate-limiting stage in the drug absorption process for medications that are poorly soluble in water. The solvent evaporation approach was used to create microspheres utilizing the polymers Eudragit L100 and Eudragit RL100. Tablets were prepared using the direct compression process. Using a rotary press machine and an 8 mm punch, tablets containing MCC and PVP K-30 as polymers was created with consistent force. A variety of evaluation tests were used to assess the manufactured tablets and microspheres. To increase the gastric residence time (GRT), a number of methods have been employed to keep the dosage form in the stomach. These methods include magnetic systems, high-density systems, mucoadhesive systems, floatation systems, unfold able, extendable, or sellable systems, and super porous hydrogen systems. The preparation and assessment of floating pioglitazone hydrochloride microspheres for the extension of stomach residence time was the goal of this investigation. Ethyl cellulose and HPMC K100M were used in the emulsion solvent diffusion-evaporation process to create the microspheres. The formulation was optimized using a full factorial design. Formulation F1 (drug: polymer 1:1), out of the three formulations made using HPMC, was determined to be the most optimal one. It had a particle size of 32.96µm, a drug entrapment efficiency of 40.46%, a yield of 91.03 percent, a buoyancy of 69.88%, and a drug loading of 20.74%. The medication release rate at the conclusion of the 12th hour was 96.42%.

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