Abstract

PLANT-DERIVED PHENOLIC COMPOUNDS AS POTENTIAL ANTI-DIABETIC AGENTS

Sagar V. Patil*, Dinesh B. Nikume, Bhavesh S. Patil, Vaibhav K. Patil and Ravindra R. Patil

ABSTRACT

Phenolic compounds (PCs), widely recognized for their diverse biological activities such as antioxidant, anti-inflammatory, and anti-diabetic properties, are secondary plant metabolites with significant pharmacological potential. This study explores the role of plant-derived phenolic compounds in combating diabetes mellitus (DM), a chronic and globally prevalent metabolic disorder. The research includes a molecular docking analysis of 29 phenolic compounds against human pancreatic alpha-amylase and other diabetes-relevant proteins. Using advanced computational tools like ChemDraw and the Schrodinger suite, the study identifies compounds such as Quercetin, L-Dopa, and Rosmarinic acid as having superior docking scores compared to standard antidiabetic drugs like Metformin and Glimepiride. The findings highlight the potential of phenolic compounds as safer and more effective alternatives to synthetic drugs, which are often associated with adverse effects like gastrointestinal disturbances and liver inflammation. The study underscores the need for further research to leverage these plant-based compounds for diabetes management, offering a promising avenue for natural therapeutics development.

Keywords: .