Abstract

EVALUATION OF ANTI-INFLAMMATORY EFFECTS OF INULA CUSPIDATA WHOLE PLANT, STEM AND FLOWER EXTRACT AGAINST CARAGEENAN INDUCED PAW EDEMA IN RATS

Ajit Kiran Kaur*, A.K.Wahi, Anil Bhandari, Sokindra Kumar

ABSTRACT

The genus Inula, one of the smallest and widest distributed genera of the family Asteraceae is comprised of 20 species in India and several of these are reported to possess medicinal properties and used in folk medicines, as tonic, stomachic, diuretic, aphrodiasic, anti-inflammatory, bactericidal. Hepatoprotective, anti-tumour and carminative. In the present study flower extract, stem extract, and whole plant extract (aqueous extract) were studied for their anti-inflammatory potential for 1hr, 2hr and 4hr duration against carageenan induced rat paw edema.. It was observed that the aqueous extract of whole plant at dose level of 400 mg/kg was found to exhibit the maximum reduction of 36.36% in edema about after 4 hours, followed by aqueous extract of stem (400mg/kg) with a reduction of about 34.54 % and least reduction was observed in aqueous extract of flower of Inula cuspidata which caused 29.09% reduction in carrageenan induced edema.

Keywords: cuspidata, aqueous extract , asteraceae, anti-inflammatory, carageenan., edema.