Abstract

THE GUT MICROBIOME: A KEY REGULATOR OF HEALTH, DISEASE AND THERAPEUTIC POTENTIAL

Vani Chatter*

ABSTRACT

The human gut microbiome plays a crucial role in metabolism, immune function, and overall health. Advances in gene sequencing have provided compelling evidence of its involvement in numerous diseases, including inflammatory bowel disease, irritable bowel syndrome, neurodegenerative disorders, metabolic disorders, and hypertension. Dysbiosis, or alterations in gut microbial composition, has been linked to these conditions, suggesting a potential avenue for novel therapeutic interventions. This review explores the gut microbiome’s influence on various diseases, emphasizing its role in inflammation, immune modulation, and metabolic regulation. Furthermore, accumulating research suggests that the microbiota-gut-brain axis plays an important role in neurodegenerative illnesses like Alzheimer's and Parkinson's. Understanding the gut microbiome's role in health and disease could lead to microbiome-targeted therapeutics such as probiotics, prebiotics, dietary changes, and microbial transplantation. This review summarizes current information about the gut microbiome's role in disease mechanisms, emphasizing the promise for microbiota-targeted therapeutics in precision medicine. Future research is critical for developing individualized microbiome therapies and identifying potential therapeutic pathways for a wide range of disorders.

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