Abstract

INFLUENCE ON PRIMACY AND NEW EMERGING ANTIMICROBIAL RESISTANCE BEHAVIOR OF URO-PATHOGEN BY VARIOUS SYSTEMIC DISEASES FOUND IN RAIPUR CHHATTISGARH AREA

Shubhra Sharma, Pallavi Shukla, Shishir Vind Sharma*, Shilpa Sharma, Avidha Shrivastava and Siddhartha Kumar

ABSTRACT

Bacteria considered uro-pathogen, frequently infecting the urinary tract of populations worldwide, while the treatment inappropriate recommendations of antibiotic promote the bacterium to be converted into multidrug resistant by using some enzymatic strategies. Correlation with previous research studies alluding about new emerging multiple drug resistance behaviour and the prevalence as per the changing era therefore the present study is trying to estimate the distribution, prevalence, and new emerging behaviour of recently isolated uro-pathogens of Raipur Chhattisgarh. Hence, for experimentation, clean mid-stream urine samples were collected between 1st July 2023 to 30th December 2023 with standard operating procedure of the hospital whereby cultivation on blood agar and MacConkey agar medium were performed. Afterward, identification ofthe bacterium was performed with automatic biochemical identification system known as VITEK 2. Antibiotic susceptibility test has then been performed as per the guideline of the hospital standards. Resulting prevalence of currently isolated bacteria in infected urine of the populations suffering from 39 different health issues were registered in the study period. Correlation between these systemic health complications and urinary tract infection illuminating chronic kidney disease, wherein the maximum samples of Klebsiella pneumoniae and Escherichia coli have been found. In the opposite, the prevalence of Pseudomonas aeruginosa was equally divided into 05 different health complication, including chronic kidney disease. In addition, among these health complications, out of 15 different organisms wherein Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa have been found as most prevalent pathogens. Consequently, all of the above organisms, Pseudomonas aeruginosa has been occurred with the lowest prevalence but depicting different emerging behaviour with respect to stranded antibiotic strategy. Whereas Klebsiella pneumoniae has been found most resistant and prevalent organism. In addition, these organisms have collectively been found susceptible against the antibiotics which are used for blocking the membrane functions only. Thus, in this study it has been concluded that blocking the membrane functions is the best.

Keywords: Uro-pathogens, Urinary infection, Antibiotic susceptibility, ViTeck-2, Klebsiella pneumoniae, Staphylococcus epidermidis, Escherichia coli, Vancomycin Resistant Enterococcus.