Abstract

SOLID LIPID NANOPARTICLES: A REVOLUTIONARY APPROACH FOR ORAL DRUG DELIVERY

Gyati Shilakari Asthana*, R. Sai Yasvitha, G. Viswas Chowdary, T.N.C. Abhiram

ABSTRACT

Oral drug delivery is the most preferred route of administration due to its convenience, patient compliance, and cost-effectiveness. However, several challenges, such as poor bioavailability, instability in the gastrointestinal tract, and first-pass metabolism, hinder the effective oral delivery of many drugs. Solid Lipid Nanoparticles (SLNs) have emerged as a promising drug delivery system to overcome these limitations. Lipids form stable colloidal systems known as solid lipid nanoparticles (SLNs), which stay solid at body and room temperatures.The medicine is either dissolved or distributed within a solid lipid core that is stabilized by a surfactant. In pharmaceutical and cosmetic formulations, SLNs were initially launched in the early 1990s as a substitute for solid nanoparticles, emulsions, and liposomes. These nanoparticles can be made from various precursors, including emulsions and microemulsions, which are then processed using varioustools and methods to produce the appropriate particle size and form. Every precursor has unique benefits, but there are drawbacks as well. SLNs are frequently prepared via high-pressure homogenization (HPH), which produces submicron-sized particles reliably by increasing shear stress and cavitation. SLNs offer advantages such as improved solubility, controlled drug release, enhanced bioavailability, and protection of drugs from enzymatic degradation, active targeting and, and multifunctional therapy. They are also particularly useful for drug delivery and the treatment of chronic illnesses since they employ biocompatible materials that allow for efficient gastrointestinal penetration. This review explores the potential of SLNs as an innovative approach to oral drug delivery, their formulation strategies, advantages, limitations, application patents, and future perspectives.

Keywords: Solid lipid nanoparticle, Oral delivery method of preparation, application, patents.