Abstract

A COMPREHENSIVE REVIEW: SUBLINGUAL DRUG DELIVERY SYSTEM

Tanaya Sunil Pawar* Ganesh Virsen Taware and Sakshi Sushant Rashinkar

ABSTRACT

Sublingual drug delivery technologies, which provide quick absorption, high bioavailability, and reduced first-pass metabolism, have become a competitive alternative to conventional oral routes. Because of its high vascularization, the sublingual vein provides direct access to the systemic circulation, avoiding the liver and gastrointestinal tract. This method works especially well for emergency therapies like reversing an opioid overdose and for medications having a high first-pass metabolism, like fentanyl, buprenorphine, and glyceryl trinitrate. Because of its quick onset of action, convenience of administration, and lower risk of gastrointestinal side effects, the sublingual route also provides better patient compliance. Additionally, sublingual formulations can be made to meet specific therapeutic demands by offering controlled, sustained, or rapid release of the active pharmaceutical ingredient. Sublingual drug delivery systems do have several drawbacks, though, such as alow dosage capacity, the possibility of local discomfort, and irregular absorption rates. Researchers are investigating novel formulation techniques, such as the application of lipid-based systems, mucoadhesive polymers, and nanoparticles, to get around these obstacles. In conclusion, sublingual drug delivery systems present a viable pathway for systemic absorption, delivering therapeutic agents in a timely, effective, and patient-friendly manner.

Keywords: Sublingual drug delivery, emergency, first pass metabolism, Competitive alternative etc.