Abstract

FORMULATION AND EVALUATION OF SUSTAIN RELEASE MATRIX TABLET DILTIAZEM HCL

Anjali S. Bawaskar, Vinod S. Chaware, Tejas J. Sharma*, Shivshankar D. Mhaske, Sachin D. Chalge

ABSTRACT

Standards in the modern pharmaceutical design and intensive research for achieving better drug product effectiveness, reliability and safety. Oral sustained release drug delivery (OSRDD) medication will continue to account for the largest share (up to 80%) of drug delivery systems. The matrix tablet preparation appears to be most attractive approach for the process development and scale-up point of view. A calcium channel blocker, Diltiazem hydrochloride has found its applicability in cardiovascular diseases advised to take the long-term treatment of cardiovascular medicaments like anti-anginals, anti-hypertensives, etc. The calcium channel blockers are utilized as the potential agents for the treatment of these diseases. They are considered as a slow calcium channel blocker.

Keywords: Diltiazem Hcl, Sustain Release, Formulation, Evaluation.