Abstract

HEREDITARY CAUSES OF PARKINSON'S DISEASE: A GENETIC OVERVIEW

Tanuja S. Pagar*, Ghanshyam B. Jadhav, Pooja V. Bombale, Bhagyashri D. Thombare, Dipali D. Warghade and Urmila M. Aware

ABSTRACT

The loss of dopaminergic neurons in the substantia nigra causes Parkinson's disease (PD), a widespread and incurable neurodegenerative illness that is primarily defined by a progressive loss of motor function. It has been estimated that around 25% of the risk for Parkinson's disease is due to genetic factors. Familial parkinsonism has been demonstrated to be caused by mutations in many genes. SNCA, LRRK2, Parkin, PINK1, DJ1, ATP13A2, PLA2G6, FBXO7, UCHL1, GIGYF2, HTRA2, and EIF4G1, TMEM230, DNAJC6) are covered in this study, which offers a thorough and critical summary of the state of clinical, neuropathological, and genetic knowledge on hereditary variants of Parkinson's disease. In this study, we provide a summary of the known genetic risk factors for Parkinson's disease (PD), emphasizing the wider networks that have been linked after thorough pathway analysis rather than specific variations. as PD genetics advances beyond The loss of dopaminergic neurons in the substantia nigra causes Parkinson's disease (PD), a widespread and incurable neurodegenerative illness that is primarily defined by a progressive loss of motor function. It has been estimated that around 25% of the risk for Parkinson's disease is due to genetic factors. Familial parkinsonism has been demonstrated to be caused by mutations in many genes. SNCA, LRRK2, Parkin, PINK1, DJ1, ATP13A2, PLA2G6, FBXO7, UCHL1, GIGYF2, HTRA2, and EIF4G1, TMEM230, DNAJC6) are covered in this study, which offers a thorough and critical summary of the state of clinical, neuropathological, and genetic knowledge on hereditary variants of Parkinson's disease. In this study, we provide a summary of the known genetic risk factors for Parkinson's disease (PD), emphasizing the wider networks that have been linked after thorough pathway analysis rather than specific variations. as PD genetics advances beyond 

Keywords: Familial Parkinsonism, Genetic Factors, LRRK2, Parkinson's Disease (PD), Predictive Models, SNCA.