Abstract

PREPARE THE FORMULATION OF SYRUP FROM ABELMOSCHUS FICULNEUS ROOTS FOR PROVE THE ANTICANCER ACTIVITY ON THE CELLS

Pratik Vijay Kale*, Prasad Tanaji Sawant, Dnyanvalkya Mangesh Patil, Vishwajeet Sanjaykumar Kalbage, Ashish Manoj Mokashi, Chaitanya Ashok Sawant, Tushar Ravsaheb Waghmare

ABSTRACT

Abstract for Abelmoschus ficulneus roots, ghee, Jaggery and honey used for cancer treatment. Abelmoschus ficulneus roots, when combined with honey, jaggery, and ghee, are traditionally used in tablet form as a potential cancer treatment approach. The combination of these ingredients is believed to enhance medicinal properties and efficacy. Key Observations: The roots contain phytochemicals with potential anti-cancer properties, Traditional preparation involves combining the roots with honey, jaggery, and ghee, The tablet formulation is designed to improve the medicinal effectiveness of the plant extract. While the search results suggest promising potential, further scientific research is needed to definitively establish the anticancer mechanisms and efficacy of this traditional preparation. How effective is Abelmoschus ficulneus in treating different types of cancer. While the search results do not specifically discuss Abelmoschus ficulneus, they provide insights into related Abelmoschus species and their potential anticancer properties. Key Observations: Abelmoschus moschatus extracts showed significant cytotoxic activity against Hep G2 cell lines, with potential to protect or treat cancer cells1 Phytoconstituents like megastigmatrienone, phytol, and loliolide possess antioxidant and antitumor properties1 Abelmoschus esculentus demonstrated promising cytotoxic activity against diverse cancer types, particularly in breast cancer models. Limitations: The research is preliminary and requires further investigation. Most studies focus on other Abelmoschus species, not specifically A. ficulneus, More comprehensive in vivo and clinical studies are needed to establish definitive anticancer efficacy. The available evidence suggests potential anticancer properties in Abelmoschus species, but direct research on A. ficulneus is lacking in these search results. What are the latest findings on the anticancer properties of Abelmoschus ficulneus. The search results provide limited but intriguing insights into Abelmoschus ficulneus and its potential anticancer properties: Key Findings: Roots of A. ficulneus, when combined with honey, jaggery, and ghee, are traditionally used for potential anti-cancer activity. The plant is recognized in Ayurvedic medicine as a Rasayana with immunomodulatory potential. Extracts of the plant demonstrate immunostimulatory effects that may have implications for immune-related diseases. Immunological Observations: Leaf extracts showed significant increase in antibody responses against immunosuppression Extracts at 200 mg/kg dose exert immunostimulatory effects on specific and non-specific immune systems. Potential Mechanisms: The roots may help prevent oxidative stress, which is linked to cancer development. Chemical constituents suggest potential as an immunotherapeutic agent. Limitations: Research is preliminary and mostly focused on immunomodulation, Direct anticancer mechanisms are not conclusively establishe, More comprehensive studies are needed to validate anticancer properties. Honey used for cancer treatment. Honey shows promising potential as a natural anticancer agent through multiple mechanisms: Key Anticancer Properties: Significantly reduces tumor growth in breast cancer models. Inhibits cancer cell proliferation by arresting cell cycle. Demonstrates dose-dependent antiproliferative effect specific Findings: Manuka honey reduced tumor growth by 84% in mice with ER-positive breast cancer. Activates critical intracellular signaling pathways like AMPK and inhibits mTOR signaling. Modulates immune system and strengthens immune cell functions. Mechanisms of Action: Induces apoptosis, Provides anti-inflammatory effects, Contains polyphenols that contribute to anticancer activity, Interferes with multiple cell-signaling pathways. Important Considerations: Most studies are preclinical (in vitro and animal models). More research is needed to validate effects in human clinical trials. Different honey types may have varying anticancer potentials Researchers emphasize the need for further investigation to fully understand honey’s potential as a complementary cancer treatment. Ghee used for anticancer disease. Ghee demonstrates promising anticancer properties through multiple mechanisms: Key Anticancer Mechanisms: Contains Conjugated Linoleic Acid (CLA) that induces cancer cell apoptosis. Enhances detoxification enzymes that neutralize cancer-causing substances. Reduces carcinogen activation in liver and mammary tissues. Scientific Evidence: A study in the Journal of Nutrition showed ghee reduced cancer metastases in mice with breast cancer, Ghee from grass-fed cows has higher CLA levels, which inhibits tumor growth. Reduces enzyme activities responsible for carcinogen activation. Upregulates carcinogen detoxification activities in liver and mammary tissues. Additional Benefits: Contains butyric acid with antiviral and anti-cancer properties, Provides Vitamin D that promotes apoptosis and slows cancer cell multiplication, Reduces cancer incidence by 39% in experimental rat studies. Important Caveat: Ghee should be consumed in moderation, adhering to recommended fat intake limits. Jaggery used in cancer treatment Jaggery shows potential anticancer properties primarily through its antioxidant capabilities: Anticancer Mechanisms: Contains phenolic acids that help reduce oxidative stress. Rich in antioxidants that fight harmful free radicals. May lower risk of chronic diseases, including cancer. Key Findings: Antioxidants in jaggery are linked to reduced cancer risk, Helps combat free radicals that can contribute to cancer development, Provides protective effects against cellular damage. Important Considerations: Research is preliminary and mostly focused on preventive potential. Jaggery is not a direct cancer treatment but may support overall health Should be consumed in moderation due to high sugar content. While promising, more comprehensive clinical studies are needed to definitively establish jaggery’s anticancer properties.

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