Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

INFLUENCE OF NATURAL GUMS ON THE SUSTAINED RELEASE MATRIX TABLETS OF METOPROLOL

*Sai kumar. M, Sumana. K, Someswara Rao.B, Suresh V. Kulkarni

ABSTRACT

Gums are widely used natural excipients for conventional and novel dosage forms. With the increasing interest in polymers of natural origin, the pharmaceutical world has compliance to use most of them in the formulations. In recent years, there has been a tremendous development in natural products which are need to be used for a variety of purposes. Nature has provided us a wide variety of materials to help improve and sustain the health of all living things either directly or indirectly. These natural materials have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, biodegradable and widely available. They can also be modified in different ways to obtain tailor made materials for drug delivery systems and thus can compete with the available synthetic excipients. Moreover, the tremendous orientation of pharma world towards these naturally derived polymers has become a subject of increasing interest to discover, extract and purify such compounds from the natural origin. Gums are potent candidate to be used in various pharmaceutical formulations as a potential candidate for novel drug delivery system (NDDS). In this review, we describe the developments in natural gums for use in the pharmaceutical sciences. Sustained release formulation is the drug delivery system that is designed to achieve a prolonged therapeutic effect by control the drug release within the safety range over an extended period of time after administration of single dose. The objective of this research work was about influence of natural gums on sustained release matrix tablets of Metoprolol succinate for the treatment of hypertension Matrix tablets were prepared by direct compression method using natural polymers, and fillers like Xanthun gum,Locust bean gum, and Karaya gum as matrix forming agent and excipients such as MCC, Lactose, Magnesium stearate and Aerosil were used. Dissolution profiles were studied in medium pH 1.2 HCl for 2 hours and pH 6.8 phosphate buffer for the remaining 10 hours. The influence of variables like polymer concentration, combination and fillers on drug release were analyzed from formulation F-1 to F-12. The formulation was optimized on the basis of acceptable tablet properties and in-vitro drug release. Formulation (F-3) successfully sustained the release of drug up to 12 hours. The release data were fit into different kinetic models (zero-order, first-order, Higuchi’s equation and Korsmeyer ‐ Peppas equation). Tablets prepared were analyzed by using FT-IR stability studies. The mechanism of drug release from F-3 was anomalous (non Fickian) diffusion. Optimized formulation F-3 was stable after stability studies under accelerated temperature and humidity.

Keywords: Metoprolol succinate, xanthan gum, locust bean gum, MCC, magnesium stearate and Aerosil.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More