Abstract

DEVELOPMENT AND IN-VITRO EVALUATION OF METOPROLOL TARTRATE LOADED CROSS LINKED POLYSACCHARIDE MICROBEAD FOR CONTROLLED DELIVERY

Keerti Ahirwar*, Shilpi Rawat, Prashansa Tripathi and Deepa Singh Chouhan

ABSTRACT

The goal of this work was to develop and test carrageenan gel beads as a new Metoprolol succinate-controlled medication release method, and therefore the drug release's reliance on bead formation. The melting point of pure Metoprolol tartrate was determined to be between 118.66±1.52 and 120.66±1.53 degrees Celsius. The absorption maxima of Metoprolol tartrate were found to be at 223 nm, which is consistent with previous findings. Water is extremely soluble in metoprolol tartrate, which is followed by a 6.8 pH Phosphate buffer. All of the formulations were made into spherical with the exception of MB1, MB4, and MB5, the formulation was MB1, MB4, and MB5. The percentage yield and percent drug entrapment of all formulations were determined to be 83.06%±1.00 to 98±0.66% and 55.06%±0.26 to 94.74%±0.39., respectively. Formulation MB7 had the highestpercentage yield and percentage drug entrapment at 98.66% and 94.74 percent, respectively. All prepared Metoprolol tartrate beads were between 8.68±2.08 and 17.96±1.52mm in size. The minimal bead size in the MB7 formulation is 8.682.08 mm. Formulation MB7 was chosen for additional in-vitro drug release testing based on the results of the following criteria. In comparison to immediate release 61.93±0.14 of pure medication, formulation MB7 demonstrated a sustained release of 95.56±0.65 at 24 hours. For the optimized formulations, the % drug release vs time (zero order), log percent drug remaining and time (first order). Considering the determination coefficients, Korsmeyer and Peppas Exponential Equation were found (R2=0.932) to fit the release data best.

Keywords: Microbeads, Metoprolol tartrate, Drug entrapment, Sustained release.