Abstract

NANOEMULSIONS AS OPHTHALMIC DRUG DELIVERY SYSTEM

Samarth Santosh Londhe, Sudip Dilip Kittad* and Atharva Balaji Komkar

ABSTRACT

Liquid-in-liquid dispersions with droplet sizes of around 100 nm are known as nanoemulsions. They have longer shelf life, a high rate of bioavailability, and a translucent look. Oil, water, surfactant, and cosurfactant make up the majority of nanoemulsions, which may be made using both high- and low-energy techniques. Because diluted nanoemulsions may enter the deep layers of the ocular structure, give a prolonged release effect, and lessen the frequency of administration and adverse effects, they are used to administer ophthalmic medications. These nanoemulsions undergo a number of testing, including rheological investigations, safety, stability, and pH profiles. . Cationic nanoemulsions are made for topical ophthalmic administration of cationic agents' active components in order to prolong the duration of the drug's residency on the ocular surface, decrease its removal fromthe surface, and enhance its bioavailability. The primary features of nanoemulsions, ophthalmic nanoemulsions, cationic nanoemulsions, and their constituents, as well as preparation techniques and assessment criteria for ophthalmic nanoemulsions, are compiled in this review article.

Keywords: ocular medication delivery, cationic nanoemulsions, and nanoemulsion.