Abstract

MICROSPHERE ENCOATED AZELAIC ACID: A COMPREHENSIVE REVIEW

Nutan Rohane, Nidhi Shirke, Aditya Singh, Kaustubh Thapa, Sujata Yadav* and Sonali Savalgi

ABSTRACT

This study investigates the formulation and evaluation of azelaic acid microspheres for topical acne treatment. Azelaic acid, sodium alginate, and calcium chloride were used as the drug, polymer, and cross-linking agent, respectively. Microspheres were prepared using the ionotropic gelation method and characterized for particle size (210-240 µm) and entrapment efficiency (38-55%). The optimal microsphere formulation (M3) was incorporated into a cream and evaluated for physical properties, pH (5.1-6.0), spreadability (5.62-10.24 (link unavailable)), and microbial growth (no growth observed). Drug content analysis revealed 75.42-85.51% drug loading, with formulation F5 showing the highest content. In-vitro drug release studies demonstrated controlled release over 6 hours, with 68.81% drug release. The results suggest that azelaic acid microsphere-based cream is a promising controlled-release dosage form for acne treatment. The formulation exhibited favourable physical properties, pH, and spreadability, ensuring skin compatibility and patient compliance. The controlled drug release profile and high drug entrapment efficiency make this formulation suitable for prolonged action. Further clinical trials and long-term stability studies are recommended to validate the efficacy and safety of this formulation in dermatological applications.

Keywords: - Particle size: 210-240 µm - Entrapment efficiency: 38-55% - pH: 5.1-6.0 - Spreadability: 5.62-10.24 (link unavailable) - Drug content: 75.42-85.51% - In-vitro drug release: 68.81% over 6 hours This study demonstrates the potential of azelaic acid micros